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Lupus - Symptoms & causes - Mayo Clinic
Overview Lupus is a condition in which the body's immune system attacks its own tissues and organs. This is called an autoimmune condition. Lupus causes swelling and irritation, called inflammation, that may affect joints, skin, kidneys, blood cells, brain, heart and lungs.

Lupus: What It Is, Symptoms, Causes & Treatment
Lupus is an autoimmune disease that makes your immune system damage organs and tissue throughout your body. It causes inflammation that can affect your skin, joints, blood and organs like your kidneys, lungs and heart.

Lupus: Symptoms, Causes, Complications, and Treatment - WebMD
When you get Lupus, your immune system attacks your tissues, leading to various illnesses. Learn more about symptoms, complications, causes, types, diagnosis, & treatment options.

Lupus - Wikipedia
Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. [1]

Lupus - Diagnosis & treatment - Mayo Clinic
Because the symptoms of lupus are like those of so many other conditions, your healthcare team must rule out other illnesses before diagnosing lupus. Depending on your symptoms, you may need to see other specialists to help with diagnosis and treatment.

Lupus Basics | Lupus | CDC
Lupus Basics Key points Lupus is a long-term, autoimmune disease that affects many parts of the body. There can be many different signs and symptoms of lupus, which makes it hard to diagnose. Lupus has no cure, but medicines and lifestyle changes can help treat and manage it.

What is lupus? - Lupus Foundation of America
Find out more about lupus: the symptoms, types, causes, and who is at risk for developing this chronic autoimmune disease.

Lupus | Lupus | CDC
CDC provides information and resources to help raise awareness about lupus and improve overall health of people with lupus. Learn more about lupus, its symptoms, causes, and treatment options.

What is systemic lupus erythematosus (SLE)?
Systemic lupus erythematosus (SLE) is the most common form of lupus — it’s the type that 7 in 10 people with lupus have. It's what most people mean when they say "lupus."

10 Early Signs of Lupus: How to Identify Them - Healthline
Lupus is an autoimmune disease that causes inflammation in different parts of the body. Learn more about the early signs and symptoms of lupus.

* Rheumatology101 News Today

          News Filter: "lupus"

What doctors want patients to know about lupus  American Medical Association | AMA
A North Carolina Mother Struggling with Lupus for Years Finds Relief at UNC School of Medicine  news.unchealthcare.org
“I refuse to let lupus get me down”: A lupus patient's story  Johnson & Johnson
Lupus & You Webinar Recap: Protecting Your Kidneys  Lupus Foundation of America
Molly J.'s Story  HSS | Hospital for Special Surgery
UCI Health launches promising clinical trial using CAR T-cell therapy to treat lupus  ABC7 Los Angeles
Pregnancy With Lupus Is Risky. Would She Be Able to Carry Her Baby to Term?  The New York Times
First Potential Probiotic Treatment for Lupus Identified at UT San Antonio  Mega Doctor News
Herbal Supplements May Up Your Lupus Flare Risk  HealthCentral
I'm a doctor, here are the hidden signs you could have an autoimmune disease  Newsweek
Doctors Thought This Mother Had Everything From Ringworm to Leukemia. After 19 Years She Got the Right Diagnosis  People.com
What Is Giant Cell Arteritis? These Are the Signs You Could Have It  CreakyJoints
The 10 Best Mobile Apps for Managing Lupus  WebMD
12 Subtle Symptoms of Lupus Doctors Want You to Know  prevention.com
‘I Thought Feeling This Bad Was Normal’: The Overlooked Signs Your Lupus Needs More Attention  Flow Space

Common Rheumatological Symptoms

Joint Pain (Arthralgia) — Persistent discomfort or soreness in one or more joints caused by inflammation, wear and tear, or underlying autoimmune responses.
Morning Stiffness — Reduced joint mobility and tightness upon waking, often lasting over 30 to 60 minutes in inflammatory conditions like rheumatoid arthritis.
Joint Swelling and Edema — Visible enlargement of affected joints resulting from fluid accumulation in the synovial membrane and inflamed surrounding tissue.
Localized Warmth and Redness — Elevated temperature and erythema skin discoloration surrounding inflamed joints due to increased blood flow from localized inflammation.
Systemic Fatigue — Overwhelming exhaustion and lack of energy caused by ongoing chronic inflammatory cytokine activity throughout the body.
Raynaud's Phenomenon — Temporary color changes in fingers or toes turning white, blue, and red in response to cold or stress due to vascular spasms.
Malar or Butterfly Rash — Red or purplish facial rash spanning across the bridge of the nose and cheeks, classically associated with systemic lupus erythematosus.

Milestones in Rheumatology History

c. 400 BC: Hippocratic Corpus Coining — Hippocrates uses the term "rheuma" to describe body humors flowing into joints, establishing the early classical concept of joint inflammation.
1592: Formal Definition of Rheumatism — French physician Guillaume de Baillou introduces the modern term "rheumatism" to distinguish systemic acute arthritis from localized gout.
1800: Clinical Description of Rheumatoid Arthritis — Augustin Jacob Landré-Beauvais publishes the first detailed clinical description separating rheumatoid arthritis from gout, calling it "asthenic gout."
1859: Naming of Rheumatoid Arthritis — Sir Alfred Baring Garrod formally coins the term "rheumatoid arthritis" to clearly differentiate the inflammatory autoimmune condition from osteoarthritis and gout.
1940: Discovery of the Rheumatoid Factor — Erik Waaler discovers autoantibodies in the blood of patients with rheumatoid arthritis, laying the groundwork for serological autoimmune diagnostics.
1948: Introduction of Corticosteroid Therapy — Philip Hench and Edward Kendall demonstrate the dramatic anti-inflammatory effects of Compound E (cortisone) in treating rheumatoid arthritis, earning the Nobel Prize.
1998: Emergence of Biologic DMARDs — The FDA approves the first TNF-alpha inhibitors, ushering in the modern era of targeted biologic therapies for autoimmune rheumatic diseases.

Current Trends in Rheumatology Research

Chimeric Antigen Receptor (CAR) T-Cell Reset Therapy — Investigating engineered cellular therapies to achieve drug-free, durable clinical remissions by completely depleting pathogenic autoantibodies in severe refractory lupus and systemic sclerosis.
Selective TYK2 and Oral JAK Pathway Inhibition — Developing highly targeted, small-molecule oral inhibitors like deucravacitinib that disrupt specific cytokine signaling pathways while minimizing broader off-target side effects.
Targeted Pathogenic T-Cell and B-Cell Depletion — Evaluating novel biologics, such as rosnilimab and ianalumab, designed to selectively deplete overactive immune cell subpopulations involved in rheumatoid arthritis and Sjögren's disease.
Biomarker-Driven Precision Medicine — Utilizing pharmacogenomics and molecular biomarkers to predict individualized therapeutic responses and match systemic autoimmune conditions to specific biological mechanisms.
Subclinical Interception and Disease Prevention — Identifying seropositive individuals early using high-risk autoantibody profiles to initiate preventive targeted therapies before irreversible joint damage occurs.
Artificial Intelligence and Predictive Disease Modeling — Deploying machine learning algorithms across electronic health records and imaging modalities to forecast inflammatory flares and refine diagnostic accuracy.