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Vasculitis - Symptoms and causes - Mayo Clinic
Vasculitis involves swelling and irritation, called inflammation, of blood vessels. The inflammation can cause the walls of the blood vessels to thicken. This thickening can narrow the vessels. If the narrowing restricts blood flow, it can damage organs and tissues. There are many types of vasculitis. Most of them are rare. Vasculitis might affect just one organ or several. The condition can ...

Vasculitis: Symptoms, Types & Treatment - Cleveland Clinic
Vasculitis is an autoimmune disorder that causes inflammation (swelling) in your blood vessels.

Vasculitis - Wikipedia
Vasculitis is a group of disorders that destroy blood vessels by inflammation. [2] Both arteries and veins are affected. Lymphangitis (inflammation of lymphatic vessels) is sometimes considered a type of vasculitis. [3] Vasculitis is primarily caused by leukocyte migration and resultant damage. Although both occur in vasculitides, inflammation of veins (phlebitis) or arteries (arteritis) on ...

Vasculitis: Types, Symptoms, Causes, Diagnosis, Treatment and More - Health
Vasculitis causes inflammation of your blood vessels, leading to symptoms like fatigue, fever, and joint pain. Early treatment can prevent organ damage.

Types of Vasculitis : Johns Hopkins Vasculitis Center
Types of Vasculitis There are approximately 20 different disorders that are classified as “vasculitis”. “ Angiitis ” and “ Arteritis ” are both synonyms for vasculitis, literally meaning “inflammation within blood vessels” or “inflammation in arteries.”

Vasculitis - Diagnosis and treatment - Mayo Clinic
Learn more about the diagnosis and treatment of Vasculitis. Find tips to get ready for any appointments you need.

Symptoms of Vasculitis - Johns Hopkins Vasculitis Center
The term “vasculitis” refers to a group of inflammatory diseases that cause inflammation centered in the wall of blood vessels. This vascular inflammation ultimately leads to damage and dysfunction of the organs that contain the affected vessels. The symptoms of vasculitis depend on the particular blood vessels (and organs) that are involved by the inflammatory process. As a group, the ...

Vasculitis - NHS
Vasculitis is the name of a group of conditions that cause inflammation of the blood vessels. Inflammation is your immune system's natural response to injury or infection. It causes swelling and can help the body deal with invading germs. But in vasculitis, for some reason the immune system attacks healthy blood vessels, causing them to become swollen and narrow. This may be triggered by an ...

Vasculitis - American College of Rheumatology
Vasculitis Vasculitis is a group of rare diseases that causes inflammation of blood vessels. There are many types of vasculitis, such as giant cell arteritis (GCA), Kawasaki disease, microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA or Churg-Strauss), Behcet's, and others.

What Is Vasculitis? - NHLBI, NIH
Primary central nervous system vasculitis means the disease is located only in the central nervous system and not linked with other diseases. Secondary central nervous system vasculitis means the disease exists along with other autoimmune diseases such as lupus or rheumatoid arthritis, other forms of vasculitis, or infection.

* Rheumatology101 LATEST NEWS *

*Filter: "Vasculitis"

Q&A: Phase-Specific Relapse Predictors in ANCA-Associated Vasculitis  Physicians Weekly
Improving communication with doctors means trusting ourselves as patients  ANCA Vasculitis News
Medical Specialists to Include on Your ANCA Vasculitis Treatment Team  Everyday Health
There’s No Debating the Value of Vasculitis Summit on Webcast  Cleveland Clinic
Which Specialists Treat Your ANCA-Associated Vasculitis (AAV)?  Everyday Health
“I’m Worth the Hassle”: How One Woman with Vasculitis Takes Charge of Her Care  Amgen
Solving for ANCA-Associated Vasculitis  HealthCentral
Ashton Kutcher Likely Had an ‘Extremely Severe’ Form of Vasculitis, Doctor Explains  Rolling Stone
Ask the Experts: Living With ANCA-Associated Vasculitis  HealthCentral
Annual Incidence of ANCA Associated Vasculitis and Polyarteritis Nodosa  Physicians Weekly
Is it Vasculitis or Something More?  Cleveland Clinic
Clinical and Demographic Features of Non-IgA Vasculitis  Physicians Weekly
6 Reasons to Feel Hopeful About an ANCA-Associated Vasculitis Diagnosis  Everyday Health
Case Report: Long-Term Monitoring a Must for ANCA-Associated Vasculitis  Cleveland Clinic
Exploring the Complexities and Significance to Define Retinal Vasculitis  Physicians Weekly

Common Rheumatological Symptoms

Joint Pain (Arthralgia) — Persistent discomfort or soreness in one or more joints caused by inflammation, wear and tear, or underlying autoimmune responses.
Morning Stiffness — Reduced joint mobility and tightness upon waking, often lasting over 30 to 60 minutes in inflammatory conditions like rheumatoid arthritis.
Joint Swelling and Edema — Visible enlargement of affected joints resulting from fluid accumulation in the synovial membrane and inflamed surrounding tissue.
Localized Warmth and Redness — Elevated temperature and erythema skin discoloration surrounding inflamed joints due to increased blood flow from localized inflammation.
Systemic Fatigue — Overwhelming exhaustion and lack of energy caused by ongoing chronic inflammatory cytokine activity throughout the body.
Raynaud's Phenomenon — Temporary color changes in fingers or toes turning white, blue, and red in response to cold or stress due to vascular spasms.
Malar or Butterfly Rash — Red or purplish facial rash spanning across the bridge of the nose and cheeks, classically associated with systemic lupus erythematosus.

Milestones in Rheumatology History

c. 400 BC: Hippocratic Corpus Coining — Hippocrates uses the term "rheuma" to describe body humors flowing into joints, establishing the early classical concept of joint inflammation.
1592: Formal Definition of Rheumatism — French physician Guillaume de Baillou introduces the modern term "rheumatism" to distinguish systemic acute arthritis from localized gout.
1800: Clinical Description of Rheumatoid Arthritis — Augustin Jacob Landré-Beauvais publishes the first detailed clinical description separating rheumatoid arthritis from gout, calling it "asthenic gout."
1859: Naming of Rheumatoid Arthritis — Sir Alfred Baring Garrod formally coins the term "rheumatoid arthritis" to clearly differentiate the inflammatory autoimmune condition from osteoarthritis and gout.
1940: Discovery of the Rheumatoid Factor — Erik Waaler discovers autoantibodies in the blood of patients with rheumatoid arthritis, laying the groundwork for serological autoimmune diagnostics.
1948: Introduction of Corticosteroid Therapy — Philip Hench and Edward Kendall demonstrate the dramatic anti-inflammatory effects of Compound E (cortisone) in treating rheumatoid arthritis, earning the Nobel Prize.
1998: Emergence of Biologic DMARDs — The FDA approves the first TNF-alpha inhibitors, ushering in the modern era of targeted biologic therapies for autoimmune rheumatic diseases.

Current Trends in Rheumatology Research

Chimeric Antigen Receptor (CAR) T-Cell Reset Therapy — Investigating engineered cellular therapies to achieve drug-free, durable clinical remissions by completely depleting pathogenic autoantibodies in severe refractory lupus and systemic sclerosis.
Selective TYK2 and Oral JAK Pathway Inhibition — Developing highly targeted, small-molecule oral inhibitors like deucravacitinib that disrupt specific cytokine signaling pathways while minimizing broader off-target side effects.
Targeted Pathogenic T-Cell and B-Cell Depletion — Evaluating novel biologics, such as rosnilimab and ianalumab, designed to selectively deplete overactive immune cell subpopulations involved in rheumatoid arthritis and Sjögren's disease.
Biomarker-Driven Precision Medicine — Utilizing pharmacogenomics and molecular biomarkers to predict individualized therapeutic responses and match systemic autoimmune conditions to specific biological mechanisms.
Subclinical Interception and Disease Prevention — Identifying seropositive individuals early using high-risk autoantibody profiles to initiate preventive targeted therapies before irreversible joint damage occurs.
Artificial Intelligence and Predictive Disease Modeling — Deploying machine learning algorithms across electronic health records and imaging modalities to forecast inflammatory flares and refine diagnostic accuracy.